Selected Publication list

​Research articles (selected)

  1. Pires VB, Lohner N, Wagner T, Wagner CB, Wilkens M, Hajikazemi M, Paeschke K, Butter F, Luke B. RNA-DNA hybrids prevent resection at dysfunctional telomeres. Cell Rep. 2023 Feb 1;42(2):112077. doi: 10.1016/j.celrep.2023.112077. Epub ahead of print. PMID: 36729832
  2. ​Zieger HK, Weinhold L, Schmidt A, Holtgrewe M, Juranek SA, Siewert A, Scheer AB, Thieme F, Mangold E, Ishorst N, Brand FU, Welzenbach J, Beule D, Paeschke K, Krawitz PM, Ludwig KU. Prioritization of non-coding elements involved in non-syndromic cleft lip with/without cleft palate through genome-wide analysis of de novo mutations. HGG Adv. 2022 Dec 5;4(1):100166. doi: 10.1016/j.xhgg.2022.100166. PMID: 36589413; PMCID: PMC9795529
  3. Schumann T, Ramon SC, Schubert N, Mayo MA, Hega M, Maser KI, Ada SR, Sydow L, Hajikazemi M, Badstübner M, Müller P, Ge Y, Shakeri F, Buness A, Rupf B, Lienenklaus S, Utess B, Muhandes L, Haase M, Rupp L, Schmitz M, Gramberg T, Manel N, Hartmann G, Zillinger T, Kato H, Bauer S, Gerbaulet A, Paeschke K, Roers A, Behrendt R. Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner. J Exp Med. 2023 Jan 2;220(1):e20220829. doi: 10.1084/jem.20220829. Epub 2022 Nov 8. PMID: 36346347; PMCID: PMC9648672
  4. Duy, P. Q., Weise, S. C., Marini, C., Li, X. J., Liang, D., Dahl, P. J., Ma, S., Spajic, A., Dong, W., Juusola, J., Kiziltug, E., Kundishora, A. J., Koundal, S., Pedram, M. Z., Torres-Fernandez, L. A., Handler, K., De Domenico, E., Becker, M., Ulas, T., Juranek, S. A., Cuevas, E., Hao, L. T., Jux, B., Sousa, A. M. M., Liu, F., Kim, S. K., Li, M., Yang, Y., Takeo, Y., Duque, A., Nelson-Williams, C., Ha, Y., Selvaganesan, K., Robert, S. M., Singh, A. K., Allington, G., Furey, C. G., Timberlake, A. T., Reeves, B. C., Smith, H., Dunbar, A., DeSpenza, T., Jr., Goto, J., Marlier, A., Moreno-De-Luca, A., Yu, X., Butler, W. E., Carter, B. S., Lake, E. M. R., Constable, R. T., Rakic, P., Lin, H., Deniz, E., Benveniste, H., Malvankar, N. S., Estrada-Veras, J. I., Walsh, C. A., Alper, S. L., Schultze, J. L., Paeschke, K., Doetzlhofer, A., Wulczyn, F. G., Jin, S. C., Lifton, R. P., Sestan, N., Kolanus, W. & Kahle, K. T. Impaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydrocephalus. Nat Neurosci25, 458-473, doi:10.1038/s41593-022-01043-3 (2022).
  5. Pandey, S., Hajikazemi, M., Zacheja, T., Schalbetter, S., Neale, M. J., Baxter, J., Guryev, V., Hofmann, A., Heermann, D. W., Juranek, S. A. & Paeschke, K. Telomerase subunit Est2 marks internal sites that are prone to accumulate DNA damage. BMC Biol 19, 247, doi:10.1186/s12915-021-01167-1 (2021).​
  6. De Magis, A., Kastl, M., Brossart, P., Heine, A. & Paeschke, K. BG-Flow, a New Flow Cytometry Tool for G-Quadruplex Quantification in Fixed Cells. BMC Biology, (2021).​
  7. Gurung P., Gomes A., Martins R., Juranek S., Alberti P., Mbang-Benet D., Urbach S., Gazanion E., Guitard V., Paeschke K., Lopez-Rubio J. (2020) PfGBP2 is a novel G-quadruplex binding protein in Plasmodium falciparum Cell Microbiol. Doi:10.1111/cmi.13303​
  8. Zacheja T#, Toth A#, Haram Gi, Yang Q, Schwindt E, Kovács M, Paeschke K*, Peter Burkovics* (2020) Mgs1 protein supports genome stability via recognition of G quadruplex DNA structures FASEB J
  9. DeMagis A, Götz S, Hajikazemi M, Fekete-Szücs E, Caterino M, Juranek S.A. Paeschke K (2020) Zuo1 supports G4 structure formation and directs repair towards nucleotide excision repair. Nature Communications, 2020
  10. Zacheja T*, Toth A*, Haram Gi, Yang Q, Schwindt E, Kovács M, Paeschke K*, Peter Burkovics*, Mgs1 protein supports genome stability via recognition of G quadruplex DNA structures FASEB J, 2020 
  11. Jurkikova*, Garjarsky*, Hajikzemi*et al , JBC, 2020, May 8th
  12. Rosenbaum JC1, Bonilla B2, Hengel SR2, Mertz TM3, Herken BW2, Kazemier HG4, Pressimone CA2, Ratterman TC5, MacNary E3, De Magis A6, Kwon Y7,8, Godin SK2, Van Houten B9, Normolle DP10, Sung P7,8, Das SR5, Paeschke K4,6, Roberts SA3, VanDemark AP1, Bernstein KA11. Nat Commun. 2019 Aug 5;10(1):3515. doi: 10.1038/s41467-019-11374-8.(2019)
  13. Sauer M, Juranek SA, Marks J, De Magis A, Kazemier HG, Hilbig D, Benhalevy D, Wang X, Hafner M, Paeschke K. DHX36 prevents the accumulation of translationally inactive mRNAs with G4-structures in untranslated regions  Nat Commun. 2019 Jun 3;10(1):2421. doi: 10.1038/s41467-019-10432-5 (2019)
  14. Goetz, Pandey, Barts, Juranek, Paeschke A Novel G-Quadruplex Binding Protein in Yeast-Slx9 Molecules. 2019 May 7;24(9). pii: E1774. doi: 10.3390/molecules24091774 (2019)
  15. Schwindt, E. & Paeschke, K. Mms1 is an assistant for regulating G-quadruplex DNA structures. Curr Genet, doi:10.1007/s00294-017-0773-9 (2017).
  16. Stinus, S., Paeschke, K. & Chang, M. Telomerase regulation by the Pif1 helicase: a length-dependent effect? Curr Genet, doi:10.1007/s00294-017-0768-6 (2017).
  17. Wanzek, K., Schwindt, E., Capra, J. A. & Paeschke, K. Mms1 binds to G-rich regions in Saccharomyces cerevisiae and influences replication and genome stability. Nucleic acids research 45, 7796-7806, doi:10.1093/nar/gkx467 (2017).
  18. Kazemier, H. G., Paeschke, K*. & Lansdorp, P. M*. Guanine quadruplex monoclonal antibody 1H6 cross-reacts with restrained thymidine-rich single stranded DNA. Nucleic acids research 45, 5913-5919, doi:10.1093/nar/gkx245 (2017).
  19. Benhalevy, D. et al. The Human CCHC-type Zinc Finger Nucleic Acid-Binding Protein Binds G-Rich Elements in Target mRNA Coding Sequences and Promotes Translation. Cell reports 18, 2979-2990, doi:10.1016/j.celrep.2017.02.080 (2017).
  20. Phillips, J. A., Chan, A., Paeschke, K. & Zakian, V. A. The pif1 helicase, a negative regulator of telomerase, acts preferentially at long telomeres. PLoS genetics 11, e1005186, doi:10.1371/journal.pgen.1005186 (2015).
  21. Bochman, M. L., Paeschke, K., Chan, A. & Zakian, V. A. Hrq1, a homolog of the human RecQ4 helicase, acts catalytically and structurally to promote genome integrity. Cell reports 6, 346-356, doi:10.1016/j.celrep.2013.12.037 (2014).
  22. Paeschke, K. et al. Pif1 family helicases suppress genome instability at G-quadruplex motifs. Nature 497, 458-462, doi:10.1038/nature12149 (2013).​

Reviews


  1. Juranek S, Paeschke K. Detecting G4 unwinding. Methods Enzymol. 2022;672:261-281. doi: 10.1016/bs.mie.2022.03.034. Epub 2022 Apr 18. PMID: 35934478.
  2. Linke, R., Limmer, M., Juranek, S. A., Heine, A. & Paeschke, K. The Relevance of G-Quadruplexes for DNA Repair. Int J Mol Sci 22, doi:10.3390/ijms222212599 (2021).
  3. Caterino, M. & Paeschke, K. Action and function of helicases on RNA G-quadruplexes. Methods 204, 110-125, doi:10.1016/j.ymeth.2021.09.003 (2022)
  4. Schult, P. & Paeschke, K. The DEAH helicase DHX36 and its role in G-quadruplex-dependent processes. Biol Chem 402, 581-591, doi:10.1515/hsz-2020-0292 (2021)
  5. Kosiol N., Juranek S, Brossart P, Heine A, Paeschke K, G-quadruplexes: A Promising Target for Cancer Therapy, Molecular Cancer (2021)
  6. Paeschke K*, Burkovics P.* (2020) Mgs1 function and role at G-quadruplex structures during DNA replicationCurrent Genetics
  7. Schult P., Paeschke K* (2020) The DEAH helicase DHX36 and its role in G-quadruplex-dependent processes. doi: 10.1515/hsz-2020-0292. Biol Chem
  8. Sauer, M. & Paeschke, K. G-quadruplex unwinding helicases and their function in vivo. Biochem Soc Trans 45, 1173-1182, doi:10.1042/BST20170097 (2017).
  9. Bochman, M. L., Paeschke, K. & Zakian, V. A. DNA secondary structures: stability and function of G-quadruplex structures. Nature reviews. Genetics 13, 770-780, doi:10.1038/nrg3296 (2012).
  10. Juranek, S. A. & Paeschke, K. Cell cycle regulation of G-quadruplex DNA structures at telomeres. Curr Pharm Des 18, 1867-1872 (2012).
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