Paeschke lab "one cannot plan for the unexpected" Aaron Klug
We aim to unravel the molecular function and consequences of G4 DNA and RNA structures in healthy and diseased cells
It is known that DNA and RNA can fold into alternative structures which influence positively and negatively biological processes. However it is not clear how these alternative structures are regulated in vivo and how they challenge the genome. Our lab studies when and how G-quadruplex (G4) DNA and RNA structures form, how they are sensed by proteins and which functions and relevance they have for cellular functions. The gained knowledge on G4 and their interacting proteins and the molecular changes (e.g. genome instability) is set into context with changes during stress and immune response as well as tumorigenesis. By combining molecular, biochemical analysis with global next generation sequencing strategies we aim to determine which impact have on cell function. Fundamental scientific questions are combined with translational scientific questions to gain novel insights into clinical relevant questions.