Paeschke lab "one cannot plan for the unexpected" Aaron Klug
We aim to unravel the molecular function and consequences of G4 DNA and RNA structures in healthy and diseases cells
It is known that DNA and RNA can fold into alternative structures which influence positively and negatively biological processes. However it is not clear how these alternative structures are regulated in vivo and how they challenge the genome. Our lab studies when and how G-quadruplex (G4) DNA and RNA structures form in living cells and which functions and relevance they have for cellular functions and pathways. In particular we study the impact of G4 for DNA repair, telomere maintenance and gene regulation. The gained knowledge on G4 and their role in cells as well as their relevance for genome instability is set into context with changes during stress and immune response as well as tumorigenesis. By combining of standard fundamental biochemical and molecular experiment with translational scientific approaches we aim to transfer our gained knowledge into clinical settings.